Diablo IV: campaign route and story bosses

Order and progression

After the prologue, the first three acts are relatively open. For a first playthrough, I → II → III is easiest to track. The story then continues through IV and V to its conclusion. This route does not replace individual quest text; yellow markers and your quest log show the active step.

Prologue · Nevesk to Kyovashad

Learn movement, resources and evade while completing the opening tasks around Nevesk. Reach Kyovashad with Lorath. Visit vendors and crafters, read potion and equipment information and activate the waypoint. An early boss is a good opportunity to watch attack areas rather than only the health bar.

Act I · Fractured Peaks

Lilith’s trail leads through religious trials and Neyrelle’s search to Vhenard and eventually Lilith’s Lament. At Vhenard, focus on summoned targets and move between projectile paths. Save your escape tool for trapped positions.

At Lilith’s Lament, safe spaces and hazardous areas change. Watch cues and protective opportunities in the arena. If the fight fails, first determine whether repeated area hits or insufficient damage caused it; those problems need different changes.

Act II · Scosglen

Travel through Scosglen and follow Donan’s connection to Astaroth. Enemy packs and spirits can congest approaches. Separate dangerous groups before using your major damage cooldown. During Astaroth, fire and movement leave little room for standing still.

Move out of telegraphed attacks early rather than forcing one last hit. When the fight shifts location, follow carefully and then rebuild your attack conditions. Collect new waypoints on longer routes.

Act III · Dry Steppes

Lorath’s trail leads deeper toward Elias. Long journeys, Brol and later fights demand that resources and cooldowns work even without large packs. Test against single targets whether your build can still attack after its first damage window.

Against Brol, keep distance during dangerous melee sequences. Kill disruptive adds without dodging into fresh hazards. In recurring Elias encounters, ground markers and summoned dangers matter more than maximizing an uninterrupted stationary attack.

Act IV · a gathering storm

The earlier trails converge. The fight with Andariel is part of the story and should not be confused with her later endgame encounter. Watch constrained movement space and remove disruptive targets when they block the route.

After this stage, check newly available travel and campaign options in game. A mount makes the next long journeys more comfortable; separate such unlocks from optional farming goals to keep story progress clear.

Act V · Hawezar

The search for an answer to Elias leads into the swamps and toward the Tree of Whispers. Handle poison and ground hazards without consuming every defensive skill at once. Reposition after a dangerous phase before building damage again.

Complete the active campaign branch and then check the log. Hawezar side-quest chains provide important background but do not replace the campaign objective. Leave room for quest items and read hints when an NPC is missing.

Act VI · Caldeum and Hell

The final stretch leads through Caldeum to Duriel and into Hell. At Duriel, pools, worms and arena obstacles punish blind backpedaling. Keep an escape route clear and concentrate damage after his attacks when you can stand safely.

At Lilith, clean arena movement is decisive. React to area attacks and floor changes before optimizing damage. Story Lilith and Echo of Lilith are different challenges; a campaign victory does not prove that an endgame build is ready.

Epilogue and the next step

Finish the closing conversations rather than logging out immediately after the boss. Then choose between an expansion campaign and endgame. Enter the next stage with stable basic equipment; a fresh loot cycle is worth more than expensive perfection on an item you will soon replace.

Four specific side-quest routes

This selection adds named puzzles and quest chains alongside the main story. It is not a complete catalogue of every side quest. English quest names help match sources; old-version requirements are not treated as current seasonal bonuses.

1. Secret of the Spring

   North of Kyovashad, climb the ladder by Forsaken Quarry to the discarded note. Follow the objective to the spring. Customize the emote wheel to add Wait, use it beside the water and open the revealed chest. Simply standing still does not solve the puzzle.

2. The Way of the Three · Kehjistan

   Use Cheer at three statues: Diablo at northern Shrine of Terror northeast of Gea Kul; Mephisto’s broken head beside the northwest exit from Denshar; Baal in the ritual chamber of conquered Altar of Ruin. Return to the empty altar by Caldeum’s Gates of Hell. Enter the portal, examine the High Priest’s corpse, speak to his spirit and fight the pillar and demon waves.

3. The Heretic → A Price to Pay → Poisoned Hearts

   Speak to Vass in Zarbinzet and find Aneta in the marked area. Help with the flowers and demon attack. The automatic follow-up A Price to Pay continues through her mother Vera; Poisoned Hearts leads to Gulyas and the ritual. Finish with Aneta’s letter instead of stopping after the first quest.

4. Scales of History · Nahantu

   If an older walkthrough requires an elixir to progress, that requirement was removed in 3.0.3. Follow the current journal objective. An unobtainable old elixir is not a reason to restart all progress.

YOUR NEXT STEP

Your checklist

Saved locally on this device, shared between both languages. This counter measures guide tasks, not game progress.